منابع مشابه
Polyamines in inflammation
esults on page 257 by Soulet and Rivest implicate polyamines in controlling immune responses in the brain. Their results suggest that polyamine synthesis, if left unchecked, can cause damaging inflammatory responses reminiscent of neurodegenerative disorders. Recognition of bacterial and viral pathogens by microglial cells, the brain’s equivalent of macrophages, elicits a cascade of gene expres...
متن کاملPolyamines in intestinal growth.
The total cellular mass of the small intestine is well controlled and can adapt, with hypo- or hyperplasia, to a wide variety of stimuli. Luminal nutrients, hormonal factors and pancreatic and biliary secretions have all been implicated in the regulation of intestinal mucosal growth. The polyamines (putrescine, spermidine and spermine) and the key enzyme controlling their synthesis (ornithine d...
متن کاملPolyamines in living organisms
Natural polyamines, putrescine, spermidine and spermine are ubiquitous cell components essential for normal cellular functions and growth. Chemically these compounds are very simple organic aliphatic cations and fully protonated under physiological conditions. There is a strong correlation between proliferation rate of the cells and their polyamine contents. Adjustments of intracellular concent...
متن کاملFunctions of Polyamines in Mammals.
The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation of mRNAs enco...
متن کاملUrinary polyamines in cancer patients.
Polyamines are small hydrocarbon-amine substances which occur ubiquitously in nature (18). Because of their polycationic nature, polyamines have a strong affinity for nucleic acids in vitro, and in vivo studies indicate a possible role for these compounds in the control of rRNA metabolism (2, 4, 8—11, 13). Studies of rapid-growth systems, both normal and neoplastic, indicate that polyamine sy...
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1985
ISSN: 0146-0749
DOI: 10.1128/mr.49.1.81-99.1985